**Vitamin D3 (Cholecalciferol)
Vitamin D deficiency has been linked to diabetes and neuropathy. High doses of Vitamin D have been shown to improve symptoms associated with neuropathy.
81% of patients with neuropathy had Vitamin D deficiency compared with 60% of those without neuropathy. View Study
Vitamin D3 supplementation improved symptoms of neuropathy. View Study
A 3 year national study shows that a significant number of patients with diabetic neuropathy suffered from Vitamin D deficiency. View Study
Type 2 diabetics had lower pain scores after 3 month supplementation of Vitamin D. View Study
High dose Vitamin D supplementation in patients with painful diabetic neuropathy is associated with a significant decrease in symptoms. 
 
 
**Vitamin B12 (Methylcobalamin)
It is widely accepted that a B12 deficiency damages the myelin sheath that surrounds and protects nerves. B12 supplementation is an essential part of preventing and treating nerve damage, especially diabetic neuropathy.
 
 
Metformin, the most commonly used drug for the treatment of diabetes causes malabsorption of folic acid and B12, which worsens neuropathy symptoms.
https://www.ncbi.nlm.nih.gov/pubmed/19846797
http://www.bmj.com/content/340/bmj.c2181
View Study
Researchers have demonstrated that Vitamin B12 and folate deficiency are associated with increased levels of homocysteine.
62 percent of patients that have diabetic neuropathy, have a B12 deficiency. The administration of B12 reversed the deficiency. 
Methylcobalamin improves sensory and autonomic nerve dysfunction. 
Symptoms of neuropathy significantly improved with daily dose of 1500mcg methylcobalamin for 24 weeks
Effects of Methylcobalamin on diabetic peripheral neuropathy. 
 
**Folate as L-Methylfolate
Over half of the US population suffers from a gene mutation called MTHFR which inhibits the body’s ability to convert the folate from food into the metabolite our body can use. This can cause problems and can lead to an increased risk of disease due to unmetabolized folic acid in the body. NerveReverse uses a special form of Folic Acid called 5-MTHF or L-Methylfolate which bypasses this mutation effect to give the body what it needs without having to convert it to useable form.
 
**Benfotiamine
The most bioavailable form of B1 has roughly 5x superior absorption than Thiamine.  Benfotiamine is fat soluble and can be absorbed directly through cell membranes, which increases efficiency of transportation to the cells where it’s needed.  This keeps your B1 levels higher for longer.
 
**Pyridoxal-5-Phosphate
The active form of vitamin B6 which is already converted to usable form.  This can help remove harmful substances from the body that can damage nerves.
 
FOR BEST RESULTS USE WITH NUTRITION for NERVES CREAM